Hydrocodone Drug Interactions:

Do not take acetaminophen and hydrocodone if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result. The most serious interactions affecting acetaminophen and hydrocodone are with those drugs that also cause sedation. Numerous drugs may lead to dangerous sedation if taken with acetaminophen and hydrocodone: Talk to your doctor and pharmacist before taking any prescription or over the counter medicines. Many other drugs contain acetaminophen, especially over-the-counter pain, fever, cold, and allergy medications.